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1、 Skeletal stunting骨萎縮 Marked obesity明顯肥胖 Sterility 不育 Hypothalamic lesions下丘腦損傷 MSG INJECTED注射味精后Olney JW. SCIENCE 164: 719-721, 1969.小白鼠注射味精后出現(xiàn)大腦損傷，肥胖以及其他系統(tǒng)紊亂1969年科學(xué)雜志 Adult males (80 kg) quickly ingested MSG, 12.7 g (150 mg/kg) in solution.成年男子 （體重約80公斤）能很快吸收溶液中12.7g（約150毫克每公斤）的味精 Time (minutes)0
2、60 120 180 240P lasma GLU (nmol/ml) 100200300400 500 Arrows = meal or snack 箭頭代表攝取的食物或點心Meals: 0745, 1215, 1800 h 飲食時間：0745，1215，1800Data are means sem(n = 10)數(shù)據(jù)：均值標(biāo)準(zhǔn)差Black circle: no MSG 黑圈表示不含味精White circle: MSG.白圈表示含有味精 Time (minutes)0 60 120 180 240Plasma PROLACTIN (ng/ml) 510152025 TRH PLACEBOM
3、SGPROTEIN MEAL Stegink LD et al Am J Obstet Gynecol 122: 70-78 (1975)Monkey study.猴子實驗Highest dose (400 mg/kg iv, open circles) produced plasma GLU 70-times normal. Battaglia FC. J Nutrition 130: 974S-977S (2000) Lactating women ingested 100 mg/kg MSG in capsules with water, and milk samples were ta
4、ken at the indicated times thereafter. From: Baker GL et al., Factors influencing dicarboxylic amino acid content of human milk. In: , Filer LJ et al., ed. New York, Raven Press, 1979 , pp. 111-123.哺乳期女性加水?dāng)z入 100 mg/kg 的膠囊，對其后特定時間的母乳樣品進(jìn)行檢驗表明：這一劑量使得血液谷氨酸濃度在30-45分鐘內(nèi)從 From: Baker GL et al., Factors infl
5、uencing dicarboxylic amino acid content of human milk. In: , Filer LJ et al., ed. New York, Raven Press, 1979 , pp. 111-123.影響人體母乳二氨基酸濃度的因素谷氨酸：生物化學(xué)和生理學(xué)進(jìn)展 n Protocol A: self-styled MSG-sensitive individuals. Fasted, challenge with placebo or MSG (5 g in liquid).n實驗A：130例自認(rèn)為MSG過敏者，禁食，以安慰劑或MSG(5克液體)進(jìn)行盲
6、試。n Protocol B:Subjects had positive response of 2 symptoms toeither or both treatments in A (i.e., placebo responderstoo). Fast, challenge with 0, 1.25, 2.5 or 5 gMSG (in liquid).n實驗B: 對A中，出現(xiàn)陽性反應(yīng)的實驗對象，超過2種癥狀（例如：對安慰劑反應(yīng)也一樣）。禁食，以0，1.25，2.5或5克MSG(液體)進(jìn)行盲試。 Geha RS et al., J Allergy Clin Immunol 106:973-
7、80, 2000 n Protocol C:Subjects had positive response of 2 symptoms to 5g MSG but not placebo in A or B. Fast, placebo (suc- rose) or MSG (5 g), in capsules ( ). Do twice.n實驗C: 對A和B中陽性反應(yīng)的實驗對象-對5克MSG出現(xiàn)超過2種癥狀（對安慰劑沒有），禁食，以膠囊性的安慰劑（蔗糖）或MSG(5克)，進(jìn)行盲試。重復(fù)實驗。n Protocol D:Subjects had positive response to both
8、MSG chal-lenges in C. Fast, breakfast & placebo (sucrose)or MSG (5 g), in capsules ( ). Do three times. n實驗D: 對C中MSG治療出現(xiàn)陽性反應(yīng)的實驗對象，禁食，早餐加膠囊性安慰劑（蔗糖）或MSG(5克)，進(jìn)行盲試。重復(fù)3次實驗Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 placebo.: Geha RS et a
9、l., J Allergy Clin Immunol 106:973-80, 2000 Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 Geha RS et al., J Allergy Clin Immunol 106:973-80, 2000 CONCLUSION: Using criteria estab
10、lished by the 1995 FASEB panel, none of the individuals who claimed a sensitivity to MSG actually showed this sensitivity when tested under blinded conditions.結(jié)論：根據(jù)1995年美國實驗生物學(xué)聯(lián)合會（FASEB）制定的標(biāo)準(zhǔn)，對那些聲稱味精過敏的個體進(jìn)行雙盲試驗表明他們未表現(xiàn)出敏感性。 Stevenson DD. Monosodium glutamate and asthma. J Nutr 130: 1067S-1073S, 2000味
11、精和哮喘 2000年 營養(yǎng)學(xué)雜志. Simon RA. Additive-induced urticaria: Experience with monosodium glutamate (MSG).J Nutr 130: 1063S-1066S, 2000. Bazzano G, DElia JA, Olson RE Science 169: 1208-1209, 1970.Adult human subjects ingested a chemically-de-fined diet supplying all of the essential amino acids in optimum amounts, plus glutamic acid as the sole source of non-essential nitrogen, for 14-42 days. No subjects developed the Chinese restaurant syndrome. No changes in weight, irrita-bility, appetite or mentation were noted. 給予成人研究對象適量的化學(xué)性飲食包含所有必須氨基酸，并以谷氨酸作為非必須氮源，14-42天后，沒有發(fā)現(xiàn)中國餐館綜合癥，體重、情緒、胃口以及智力都沒有變化。
《味精安全問題》PPT課件
