《骨髓移植的幾個相關(guān)問題.ppt》由會員分享，可在線閱讀，更多相關(guān)《骨髓移植的幾個相關(guān)問題.ppt（8頁珍藏版）》請在裝配圖網(wǎng)上搜索。
1、骨髓移植的幾個相關(guān)問題 RELAPSE OF CML AFTER ALLO-BMT RELAPSE RATEnSD-ALLO-BMT CP：16 +- 2 % （3 Yr） AP：36 +- 6 % BP：61 +- 11% nSD-ALLO-BMT （HLA MISMATCHED）：nMACH LOWER THAN THAT OF MATCHED DONOR RELAPSE OF CML AFTER ALLO-BMT RELAPSE RATEnSIGNS OF CML：BCR-ABL P210 P190 RELAPSE OF CML AFTER ALLO-BMT RELAPSE RATEn
2、AFTER ALLO-BMT PCR ASSAY FOR BCR/ABL GENELESS THAN 1/2 YEAR：78% PCR+12 YEAR： 50% PCR+23 YEAR 30% PCR+34 YEAR 20% PCR+n持續(xù)PCR OF BCR/ABL 基因陽性則有復(fù)發(fā)的可能 RELAPSE OF CML AFTER ALLO-BMT RELAPSE RATEn TREATMENT OF RELAPSED CML AFTER BMT CSA WITHDROW DLI IL-2 IF-a RE-TRANSPLANTn DLI FOR RELAPSED CML LATE-ONCET
3、 OF ACUTE GvHD n TWO MONTH DELAY IN ONCET OF aGvHDGASTROINTESTINAL MORBIDITY MORE SEVERE IN “NST”GROUPn SKIN CHANGE WITH GVHD IS MORE SEVERE DONORS CHOOSING ORDER FOR BMT n HLA IDENTICAL RELATED（SIBLING ET AL） n HLA IDENTICAL UNRELATED n HLA IDENTICAL CORD BLOOD n HLA NON-IIDENTICAL UD OR CB n HLA HAPLOIDENTICAL SD，UD，OR CB n MOTHER n FATHER THE IMMUNOLOGICAL ASPECTS IN CBT n GVHD RATE AND SEVERITY ARE LESS THAN BMT n T LYMPHOCYTE CD4：NO CHANGE CD8：比例少，CD4/CD8增高 n CD3，CD8減低；NK細胞增多，T細胞穿孔素陽性細胞少 n INFECTION 多見 細菌，霉菌，病毒，原蟲，結(jié)核
骨髓移植的幾個相關(guān)問題.ppt
